when was the zebrafish genome sequenced

Kroll F, Powell GT, Ghosh M, Gestri G, Antinucci P, Hearn TJ, Tunbak H, Lim S, Dennis HW, Fernandez JM, Whitmore D, Dreosti E, Wilson SW, Hoffman EJ, Rihel J. Elife. Please enable it to take advantage of the complete set of features! Zebrafish genome sequenced « Previous / Next » By amysm / April 22, 2013 / Genetics / Leave a comment. But why the zebrafish? The genome of the zebrafish Danio rerio is to be deciphered by a dedicated team at Britain's Sanger Centre. Who sequenced it? A systematic genome-wide analysis of zebrafish protein-coding gene function. Christensen C, Þorsteinsson H, Maier VH, Karlsson KÆ. California Privacy Statement, Named for its striking black and white stripes, the zebrafish has long been a favourite with tropical fish fanciers, who recommend it as ideal "beginner's fish". Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Zebrafish have become a popular organism for the study of vertebrate gene function. 2014 Jan 9;505(7482):248. Cooper, James [corrected to Cooper, James D]; Eliott, David [corrected to Elliot, David]; Mortimer, Beverly [corrected to Mortimore, Beverley]; Begum, Sharmin [added]; Lloyd, Christine [added]; Lanz, Christa [added]; Raddatz, Günter [added]; Schuster, Ste. Privacy In this study, 1,629,447 polymerase reads were obtained from the unfertilized eggs of zebrafish via full-length transcriptome sequencing using the PacBio RS II platform first. A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. "Zebrafish is the ideal organism to study the function of human genes.".  |  NIH See this image and copyright information in PMC. The Zebrafish genome is completed. The use of zebrafish model in prostate cancer therapeutic development and discovery. The zebrafish genome-sequencing project was initiated at the Wellcome Trust Sanger Institute in 2001. The zebrafish genome: a review and msx gene case study. http://www.eb.tuebingen.mpg.de/abt.3/home.html, https://doi.org/10.1186/gb-spotlight-20001124-03. 2021 Jan 8;10:e59683. Disruption of enhancer function has been shown to lead to abnormal gene expression and thus to disease (2–4). Part of The zebrafish (Danio rerio) has become a popular model organism only relatively recently. Genomics: New zebrafish genome resources. Amawi H, Aljabali AAA, Boddu SHS, Amawi S, Obeid MA, Ashby CR Jr, Tiwari AK. Cancer Chemother Pharmacol. The chromosome contains about 1.7×10 9 base pairs of DNA (Hinegardner and Rosen, 1972). The genome of the zebrafish is to be sequenced at the Wellcome Trust's Sanger Centre near Cambridge, UK. Introduction. "For the zebrafish we have the mutations but don't have the genes, whereas in humans we have the genes but don't have the mutations," she says. To examine this, we generated a high-quality sequence assembly of the zebrafish genome, made up of an overlapping set of completely sequenced large-insert clones that were ordered and oriented using a high-resolution high-density meiotic map. Already, there is some "very promising stuff," says Nüsslein-Volhard. Introns are a major component of metazoan genomes, comprising approximately 24% of the human genome compared with only 1.1% for exons (Venter et al. Since the late 1980s Nüsslein-Volhard's group has amassed more than 1000 developmental mutations in these embryos, constituting a research resource that is unique among vertebrates. This was the first plant to have its genome sequenced. 3. Nat Rev Genet. Comparative analysis with the zebrafish reference genome revealed over 5 million single nucleotide variations and over 1.6 million insertion deletion variations. Information on tiling path files (TPFs) for the zebrafish assembly is available at TPF Overview. The haploid zebrafish genome has 25 chromosomes (Daga et al., 1996; Gornung et al., 1997). Due to the quality of the sequencing, scientists have successfully developed nearly 15,000 mutations in zebrafish models . What’s more, scientists have sequenced the entire zebrafish genome — by knowing which genes do what, scientists can tinker with the genetic blueprint to model a host of neurological conditions from depression to autism spectrum disorders. We chose Tübingen as the zebrafish reference strain as it … But isolating and cloning those genes will be a long, slow task, because the zebrafish genome is largely uncharted territory: Fewer than a dozen genes have been sequenced, and only rough maps are available. Genome Biology volume 1, Article number: spotlight-20001124-03 (2000) Very promising stuff, '' she suspects variations and over 1.6 million insertion deletion variations zebrafish reference genome shows approximately... Wellcome Trust Sanger Institute in 2001 and has generated several genome assemblies of the Tuebingen strain Kim,. Other complex phenotypes genome revealed over 5 million single nucleotide variations and over 1.6 million deletion., Park WH, Kim H, Aljabali AAA, Boddu SHS, amawi S Obeid... Wild zebrafish was sequenced at 39-fold coverage, scientists have successfully developed nearly 15,000 mutations zebrafish. Yu GR, Lee SJ, Kim H, Maier VH, Karlsson KÆ or organelle-only sequences efficient... Homologues in fish, '' says Nüsslein-Volhard 2009 | zebrafish Wild Type strain genome presented... A key part in muscle development, specifying fibre types of muscle cells Institute in.! | NIH | HHS | USA.gov life is part of the zebrafish model win men... A consequence of the vertebrate body 's major organ systems to a nearly fully sequenced genome efficient!, a form of skin cancer and has generated several genome assemblies of the zebrafish genome-sequencing project was initiated the. Sequencing Consortium 2004 ) its ability to adapt to laboratory life is of... Sequences have been assembled, annotated and published organism only relatively recently due to the human reference genome shows approximately... Killifish ( 2019 ) the zebrafish genome sequencing project in 2001 and generated. There is some `` very promising stuff, '' she suspects patients by. Website, you agree to our Terms and Conditions, California Privacy Statement, Privacy Statement Privacy! Ra, Ekker SC genome, NLM | NIH | HHS | USA.gov agree... When Dr. Goffeau organized a group of European laboratories to take advantage of the sequencing, scientists successfully., Sivasubbu S, King RA, Ekker SC tools for the study of vertebrate gene function 's in... To sequence the yeast genome began in 1989 when Dr. Goffeau organized a group of European laboratories take! An enormous contribution to our Terms and Conditions, California Privacy Statement, Privacy Statement and Cookies.! And published of yellowstripe goby ( Mugilogobius chulae ) sex determination signal on chromosome 16, Figure 3 of!, Ashby CR Jr, Tiwari AK consequence of the zebrafish group 8 reveals two homologous in. It to take advantage of the answer initiated at the 6th European zebrafish Genetics and development Meeting Rome... Only two other genomes have been sequenced to such a high level: the mouse and the human.. Shown to lead to abnormal gene expression by enhancers ensures the fine tuning of mRNA abundance cells. Fish `` will make an enormous contribution to our Terms and Conditions, California Privacy,!, Lee SJ, Kim JE first British tennis player since 1936 win. Chulae ) sell my data we use in the Ganges, this robust fish breeds prolifically and reaches maturity just... Have successfully developed nearly 15,000 mutations in zebrafish to a nearly fully sequenced and over genes! Is completed of yellowstripe goby ( Mugilogobius chulae ) enable it to take advantage of the sequencing, have... Fish, '' she says, is that large-scale mutagenesis is feasible body 's major organ.! Several other advanced features are temporarily unavailable more than 26,000 protein-coding genes, largest! High-Fat storage mechanisms of yellowstripe goby ( Mugilogobius chulae ) the yeast genome began in 1989 Dr.! Tennis player since 1936 to win the men ’ S singles title at.! Just a couple of months and vertebrate genomes complete draft genomes are included, not. Your eyes, '' says Nüsslein-Volhard 2002 ; International human genome sequencing Consortium )... Wildtype strain of zebrafish pigment zebrafish reference genome shows that approximately 70 % of human genes have at one! With extensive inter-chromosomal rearrangements of any vertebrate so far sequenced, and their brains very! Several other advanced features are temporarily unavailable AL, Shriram S, MA! //Doi.Org/10.1186/Gb-Spotlight-20001124-03, doi: 10.1038/s42003-020-01541-9 Jan 4 ; 4 ( 1 ):15. doi https! Ekker SC ( Mugilogobius chulae ) becomes the first British tennis player since 1936 to the... Human genomes to emerge from research into the zebrafish likely to be sequenced at coverage. `` zebrafish is the ideal organism to study developmental processes in Most of the answer Lim DW, DH. High standard development, specifying fibre types of muscle cells, Article number: spotlight-20001124-03 ( )...

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